| Singles competition |
| Round of 32 |
| R32 | #1 Matia Cristiani (Babson) def. #36 Katalina Wang (Case Western Reserve) 6-3, 7-5 |
| R32 | #11 Izabele Antanavicius (Emory) def. #37 Eleni Lazaridou (Kenyon) 6-2, 6-1 |
| R32 | #7 Elsie Van Wieren (Middlebury) def. #17 Jane Ling Chun Wong (Carnegie Mellon) 6-3, 6-3 |
| R32 | #19 Eleanor Archer (WashU) def. Mariella Congeni (Sewanee) 7-5, 6-4 |
| R32 | #2 Sarena Biria (University of Chicago) def. #4 Rebecca Kong (Claremont-Mudd-Scripps) 0-6, 6-4, 6-1 |
| R32 | Ginevra Muratori (Skidmore) def. Lola Diaz (Swarthmore) 6-2, 6-2 |
| R32 | #16 Lauren Rha (Pomona-Pitzer) def. Karina Elvestrom (Gustavus Adolphus) 6-3, 6-3 |
| R32 | Lauryn Douglas (Bethel (MN)) def. Aspen Young (Colorado College) 6-2, 6-3 |
| R32 | #27 Lauren Long (Washington and Lee) def. Victoria Wang (New York University) 7-6 (7-4), 7-5 |
| R32 | #20 Agnes Guggenheim (Wesleyan-CT) def. #8 Emily Kantrovitz (Emory) 6-4, 6-2 |
| R32 | #24 Clara Zou (University of Chicago) def. #3 Tina She (Amherst) 6-3, 4-6, 6-4 |
| R32 | #10 Sandra Sikharulidze (Babson) def. #12 Lindsay Eisenman (Claremont-Mudd-Scripps) 6-2, 6-2 |
| R32 | #49 Hannah Kassaie (Case Western Reserve) def. Addison Felts (Mary Washington) 7-5, 6-7 (2-7), 6-2 |
| R32 | #5 Eliana Hanna (WashU) def. #6 Ananya Sriniketh (Claremont-Mudd-Scripps) 6-7 (0-7), 6-3, 6-3 |
| R32 | #43 Lia Melvin (Johns Hopkins) def. Eva Kovachev (Trinity-TX) 6-4, 6-4 |
| R32 | #14 Saina Deshpande (Massachusetts Inst. of Tech.) def. #13 Maegan Deng (Redlands) 6-3, 6-0 |
| Round of 16 |
| R16 | #1 Matia Cristiani (Babson) def. #11 Izabele Antanavicius (Emory) 6-1, 6-4 |
| R16 | #7 Elsie Van Wieren (Middlebury) def. #19 Eleanor Archer (WashU) 6-4, 6-4 |
| R16 | #2 Sarena Biria (University of Chicago) def. Ginevra Muratori (Skidmore) 6-4, 6-2 |
| R16 | #16 Lauren Rha (Pomona-Pitzer) def. Lauryn Douglas (Bethel (MN)) 6-3, 2-6, 6-2 |
| R16 | #27 Lauren Long (Washington and Lee) vs. #20 Agnes Guggenheim (Wesleyan-CT) -- no result |
| R16 | #10 Sandra Sikharulidze (Babson) def. #24 Clara Zou (University of Chicago) 6-1, 6-4 |
| R16 | #49 Hannah Kassaie (Case Western Reserve) vs. #5 Eliana Hanna (WashU) -- no result |
| R16 | #43 Lia Melvin (Johns Hopkins) def. #14 Saina Deshpande (Massachusetts Inst. of Tech.) 7-5, 6-2 |
| Quarterfinals |
| QF | #1 Matia Cristiani (Babson) def. #7 Elsie Van Wieren (Middlebury) 6-3, 6-3 |
| QF | #2 Sarena Biria (University of Chicago) def. #16 Lauren Rha (Pomona-Pitzer) 6-3, 1-0, retired |
| QF | #10 Sandra Sikharulidze (Babson) def. #27 Lauren Long (Washington and Lee) 6-3, 7-5 |
| QF | #43 Lia Melvin (Johns Hopkins) def. #5 Eliana Hanna (WashU) 6-4, 3-6, 6-4 |
| Semifinals |
| SF | #1 Matia Cristiani (Babson) def. #2 Sarena Biria (University of Chicago) 6-3, 6-1 |
| SF | #43 Lia Melvin (Johns Hopkins) def. #10 Sandra Sikharulidze (Babson) 1-6, 6-3, 6-3 |
| Finals |
| F | #1 Matia Cristiani (Babson) def. #43 Lia Melvin (Johns Hopkins) 6-1, 6-1 |